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Randomised Exposure Study of Pollution Indoors and Respiratory Effects

Particulate Air Pollution Exposure and Childhood Acute Respiratory Infections in Guatemala: A Randomized Intervention

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01047696
Acronym
RESPIRE
Enrollment
537
Registered
2010-01-13
Start date
2002-10-31
Completion date
2005-03-31
Last updated
2010-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumonia, Respiratory Tract Infections

Brief summary

The purpose of this study was to determine whether reduced exposure to indoor air pollution would reduce ALRI incidence in children \<18 months of age. Households were randomized to receive a chimney stove (intervention group) or continue using an open fire for cooking and heating (control group).

Detailed description

Acute lower respiratory infections (ALRI) are the chief killer of children. Most cases are pneumonia and the majority occur among poor children under five years in developing countries. Poverty might be said to be the primary cause, which manifests as malnutrition, including micro-nutrient deficiencies, and lack of access to medical care. Another attribute of poverty is household indoor air pollution (HAP) from use of unprocessed solid fuels such as biomass (wood, animal dung and crop wastes) and coal in simple stoves. A meta-analysis of published observational studies found that young children exposed to smoke from household solid fuel use had a rate of ALRI twice that of children not exposed or where clean fuels were used. Recent studies have shown similar ALRI risks associated with short-term air pollution measurements and other indicators of exposure.

Interventions

DEVICEPlancha

locally developed chimney stove

Sponsors

World Health Organization
CollaboratorOTHER
Universidad del Valle, Guatemala
CollaboratorOTHER
University of Liverpool
CollaboratorOTHER
University of California, Berkeley
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
No minimum to 18 Months
Healthy volunteers
Yes

Inclusion criteria

Households were invited to participate in the study if they met the following inclusion criteria: * Used only an open fire for cooking and heating * Had a pregnant woman or child \< 4 months residing in the home * Identified as Mam (the regional ethnic group), and had * Minimal summer migration (less than 12 weeks per year)

Exclusion criteria

Households were excluded from participating if: * The household was already using a chimney stove for cooking * There was no child \<4 months of age or a pregnant woman residing in the home * Seasonal migration required the family to move to another region for more than 12 weeks of the year

Design outcomes

Primary

MeasureTime frame
The primary outcome measure was physician-diagnosed pneumonia in childrenThrough 18 months of age

Secondary

MeasureTime frame
Severe (hypoxaemic) and RSV pneumoniaThrough 18 months of age

Countries

Guatemala

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026