Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate

Ovulation Induction With Clomiphene Citrate: to Support or Not to Support the Luteal Phase

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01046708

Enrollment

300

Registered

2010-01-12

Start date

2008-09-30

Completion date

2012-07-31

Last updated

2013-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

IUI, clomiphene citrate, utrogestan

Brief summary

The purpose of this study is to assess the effect of luteal phase supplement (LPS) on pregnancy rate in IUI cycles stimulated with clomiphene citrate.

Interventions

DRUGmicronized progesterone

600mg in 3 separate doses per day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 36 Years

Healthy volunteers

Yes

Inclusion criteria

* Age ≤ 36 years * Body mass index between 18 and 29 * Presence of both ovaries * Basal levels of estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the cycle and a day three FSH level of \<12IU/L * Patients can enter the study only once. * Only the first IUI attempt will be included ( at the 2nd and 3 rd attempt progesterone could be administrated if it is necessary but these attempts will be excluded from the study) * Normal HSG (maximum 3 months prior starting the stimulation). * Donor sperm can be included

Exclusion criteria

* Polycystic ovarian syndrome (Rotterdam criteria) * Endometriosis(≥AFS III)

Design outcomes

Primary

Measure	Time frame
ongoing pregnancy rate	1 year

Secondary

Measure	Time frame
implantation rate,clinical pregnancy rate	1 year

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 31, 2026