The Analgesic Efficacy of Transversus Abdominis Plane Block After Laparoscopic Cholecystectomy

The Analgesic Efficacy of Transversus Abdominis Plane Block After Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01046071

Enrollment

Registered

2010-01-11

Start date

2010-03-31

Completion date

2011-02-28

Last updated

2011-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Cholecystectomy

Keywords

Transversus abdominis plane block, postoperative pain.

Brief summary

The purpose of this study is to determine whether Transversus abdominis plane block as part of a multimodal postoperative regimen is superior to control in analgesic efficacy after laparoscopic cholecystectomy.

Interventions

PROCEDUREtransversus abdominis plane block

UL-guided TAP block with 20 ml of ropivacaine 0,5% bilateral, single dose.

PROCEDURETAP block placebo

UL-guided TAP block with 20 ml of saline bilaterally, single dose.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Laparoscopic cholecystectomy * ASA 1-3 * BMI 18-35 * Written consent

Exclusion criteria

* Do not understand danish * Drug allergy * Pregnancy * Alcohol or drug abuse * Chronic pain with consumption of opioids * Consumption of NSAID, COX2inhibitors or paracetamol within 24 hours before the investigation * Infection at the needle site.

Design outcomes

Primary

Measure	Time frame	Description
Pain during cough.	0,2,4,6,8,24 hours postoperative	Area under the curve (AUC)-pain during cough based on measurements at 0,2,4,6,8,24 hours postoperative.

Secondary

Measure	Time frame	Description
Pain during rest	0,2,4,6,8,24 hours postoperative	Area under the curve (AUC)-pain during rest based on measurements at 0,2,4,6,8,24 hours postoperative.
Total opioid consumption	0-24 hours postoperative	Morphine consumption 0-2 hours postoperative. Ketobemidone consumption 2-24 hours postoperative.
Postoperative nausea and vomiting	0,2,4,6,8,24 hours postoperative	Nausea scores (0-3) at 0,2,4,6,8,24 hours postoperative. The number of vomits 0-2, 2-4, 4-6, 6-8 and 8-24 hours postoperative
Sedation	0,2,4,6,8,24 hours postoperative	Sedation scores (0-3) at 0,2,4,6,8,24 hours postoperative

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026