Increase the Eradication Rate of Helicobacter Pylori
Conditions
Keywords
Helicobacter pylori, Berry extract, Triple therapy
Brief summary
Helicobacter pylori (HP) is the major risk factors of gastritis, gastric ulcers, duodenal ulcers, mucosa associated lymphoid tissue lymphoma and gastric cancer. Helicobacter pylori are found in 70-90% of the population in developing countries and in 25-50% of developed countries.
Detailed description
One-week of triple therapy composed of a proton pump inhibitor plus two antibiotics is currently regarded as the gold standard for HP eradication. However, the eradication rate continues to be disappointing. Poor patient compliance and bacterial resistance are the main factors contributing to treatment failure. Therefore, it is urgently necessary to develop a non-antibiotic alternative therapy to increase the eradication rates of Helicobacter pylori. Some literatures reported that cranberry may inhibit Helicobacter pylori adhesion to the human gastric mucus and may reduce Helicobacter pylori infection in adults. The aims of his experiment were to explore the impact of berry extract on triple therapy for Helicobacter pylori eradication.
Interventions
DIETARY_SUPPLEMENTBerry extract
Berry extract for weeks
Sponsors
Shin Kong Wu Ho-Su Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients older than 18
Exclusion criteria
* Pregnancy or breastfeeding * Use of antibiotics 2 weeks prior to inclusion * Previous eradication treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate | 4 weeks after Eradication of Helicobacter pylori |
Countries
Taiwan
Contacts
Primary ContactChian-Sem Chua, MD
Outcome results
None listed