Periodontitis and Coronary Heart Disease

Conditions

Coronary Heart Disease, Periodontitis

Keywords

periodontitis and coronary heart disease

Brief summary

Atherosclerosis is an inflammatory disease. The hypothesis of an infectious burden as trigger or initiator of the inflammatory process in atherosclerosis has been extensively discussed in the past years. One part of this discussion is focused on the infectious agents responsible for periodontitis. Several studies have found an association of periodontitis and/or bacteria related to this disease and atherosclerosis. However, a study focussing on the prognostic relevance of these factors is missing. The hypothesis of this study is that periodontitis is a prognostic relevant risk factor for patients with angiographically proven coronary heart disease. Furthermore, the infectious pathogen burden by PCR-detection of periodontal pathogens will be evaluated as a prognostic factor. 960 consecutive patients with angiographically proven coronary heart disease will be included in this study. After inclusion of patients an extensive periodontal examination including PCR-sampling for 11 bacteria (Porphyromonas gingivitis, Actinobacillus actinomycetemcomitans, and others) will be performed. After 12 months patient will be follow up for any major adverse events (cardiovascular death, myocardial infarction, stroke). If this study will find a relation of periodontitis or its microbiological agents to cardiovascular outcome of patients with coronary heart disease, further studies are necessary to investigate potential therapeutic consequences for patients with CHD and periodontitis.

Reichert S, Schlitt A, Rehm S, Schulz S.

2026-03-06

10.1002/jper.70086

Severe Periodontitis is Associated With Recurrent Cardiovascular Events—A 10‐Year Longitudinal Cohort Study

Stefan Reichert, Selina Rehm, Axel Schlitt, Susanne Schulz

Journal of Periodontal Research2024-11-225 citations

10.1111/jre.13365

Major Adverse Cardiovascular Events: The Importance of Serum Levels and Haplotypes of the Anti-Inflammatory Cytokine Interleukin 10

Susanne Schulz, Leonie Reuter, Alexander Navarrete Santos, Kerstin Bitter, Selina Rehm et al. (7 authors)

Biomolecules2024-08-094 citations

10.3390/biom14080979

The Interleukin 6 Protein Level as well as a Genetic Variants, (rs1800795, rs1800797) Are Associated with Adverse Cardiovascular Outcomes within 10-Years Follow-Up

Susanne Schulz, Selina Rehm, Axel Schlitt, Kerstin Bitter, Stefan Reichert

Cells2023-11-285 citations

10.3390/cells12232722

C-Reactive Protein Level and the Genetic Variant rs1130864 in the CRP Gene as Prognostic Factors for 10-Year Cardiovascular Outcome

Susanne Schulz, Selina Rehm, Axel Schlitt, Madlen Lierath, Henriette Lüdike et al. (8 authors)

Cells2023-07-048 citations

10.3390/cells12131775

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Susanne Schulz, Martin Zielske, Sascha Schneider, Britt Hofmann, Hans‐Günter Schaller et al. (7 authors)

Mediators of Inflammation2021-01-012 citations

10.1155/2021/3002439

ANRIL polymorphisms (rs1333049 and rs3217992) in relation to plasma CRP levels among in-patients with CHD.

Reichert S, Seitter L, Schaller HG, Schlitt A, Schulz S.

2019-11-279 citations

10.1016/j.cyto.2019.154932

Periodontal pathogens and their role in cardiovascular outcome

Susanne Schulz, Axel Schlitt, Britt Hofmann, Hans‐Günter Schaller, Stefan Reichert

Journal Of Clinical Periodontology2019-11-2532 citations

10.1111/jcpe.13224

Data on IL-6 c.-174 G>C genotype and allele frequencies in patients with coronary heart disease in dependence of cardiovascular outcome.

Reichert S, Schlitt A, Benten AC, Hofmann B, Schaller HG, Schulz S.

2016-07-161 citations

10.1016/j.dib.2016.07.020

High degree of severe periodontitis in patients with coronary heart disease from Eastern Germany, but no relation to cardiovascular outcome, the PARO-CHD study

Axel Schlitt, Andrea Lutze, Andreas Wienke, Thomas Seifert‐Held, T. Dudaklieva et al. (10 authors)

European Heart Journal2013-08-02

10.1093/eurheartj/eht308.p2484

The importance of genetic variants in TNFα for periodontal disease in a cohort of coronary patients.

Schulz S, Schlitt A, Lutze A, Lischewski S, Seifert T, Dudakliewa T, Gawe R, Werdan K, Hofmann B, Gläser C, Schaller HG, Reichert S.

2012-06-1211 citations

10.1111/j.1600-051x.2012.01909.x

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Age \>18 years * Coronary heart disease as defined by previous or current detection of 50% stenosis of a main coronary artery by coronary angiography or previous or current percutaneous coronary intervention (PCI) or previous or current coronary artery bypass surgery (CABG)

Exclusion criteria

* Inability to give written informed consent * Periodontal treatment and/or antibiotic therapy during the last 6 months * Pregnancy * Current alcohol or drug abuse, or psychological reasons that make study participation impractical * Drugs which are potential causal for gingival hyperplasia (Hydantoin, Nifedipine, Cyclosporin A, and other)

Design outcomes

Primary

Measure	Time frame
Combined endpoint: myocardial infarction, cardiovascular death, stroke	12 months follow-up

Countries

Germany

Outcome results