Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma

Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma, a Methodological Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01044979

Enrollment

Registered

2010-01-08

Start date

2009-12-31

Completion date

2010-09-30

Last updated

2014-07-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colloid Osmotic Pressure

Keywords

Colloid osmotic pressure in interstitial fluid, Colloid osmotic pressure in plasma, Protein fractions in interstitial fluid

Brief summary

The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.

Detailed description

Fluid loss from circulating plasma volume is one of the contributors of oedema formation. Measurement of colloid osmotic pressure (COP) both in plasma and in interstitial fluid can be utilised in planing of fluid therapy in patients with oedema. Different methods of sampling interstitial fluid are well validated in animal models, but not in human. Sampling of interstitial fluid by subcutaneous sewn wicks is a well-known method and can be painful. Local anaesthetics can reduce pain. By comparing interstitial fluid taken from areas with or without application of local anaesthetics, a possible influence in COP values can be detected.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Adults over 18 years

Exclusion criteria

* Ongoing illness * Medication

Design outcomes

Primary

Measure	Time frame
Colloid osmotic pressure	60 and 90 minuttes after implanting wicks

Countries

Norway

Outcome results