Off Pump Coronary Artery Bypass Surgery
Conditions
Keywords
Heparin responsiveness, Off-pump coronary artery bypass graft surgery, Risk factors, Myocardial infarction
Brief summary
The investigators evaluated clinical impact of reduced heparin responsiveness (HRreduced) on the incidence of perioperative myocardial infarction (MI) and restenosis at 6 months after off-pump coronary artery bypass graft surgery (OPCAB) and identified its predictors.
Interventions
DRUGHeparin
150 U/kg heparin was administered intravenously at the beginning of graft anastomosis and accepted a perioperative ACT value of around 300 s. Ten minutes after the loading dose, the ACT was measured. An ACT of 300 s or greater was considered as adequate. Then follow up ACT measurement was determined after 30 min from the previous ACT measurement. If ACT fell below the target value of 300 s, an additional dose of heparin was administered. If ACT was between 250 and 299 s, additional 2000 U of heparin was administered and if ACT was between 200 and 249 s then additional 3000 U of heparin was injected. Ten minutes after additional heparin injection, ACT was remeasured.
Sponsors
Yonsei University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* enrolling all consecutive patients scheduled for elective isolated multivessel OPCAB between April 2007 and March 2008
Exclusion criteria
* presence of known preoperative coagulopathy, emergency operation or preoperative use of an intra-aortic balloon pump.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidences of postoperative MI and major morbidity | immediate postoperative period |
Secondary
| Measure | Time frame |
|---|---|
| incidences of cardiac morbidities | 6 months following surgery |
| restenosis of graft vessels | 6 months following surgery |
Countries
South Korea
Outcome results
None listed