Type 2 Diabetes
Conditions
Keywords
Diabetes Mellitus, Myocardial perfusion imaging, Heart diseases, Echocardiography, Endothelium
Brief summary
The investigators aimed to evaluate microvascular circulation with novel method: real-time myocardial contrast echocardiography in patients with type 2 diabetes and normal coronary arteries. Myocardial blood flow reserve will be determined by quantitative contrast Stress echocardiography. Diabetic individuals will be evaluate in a decompensated state (Phase 1) and after optimization of medical treatment four months later (Phase 2).
Detailed description
Early stages of epicardial atherosclerosis in patients with type 2 diabetes are associated with an impairment in endothelium-dependent dilation of the coronary microvasculature, indicating that the pathophysiological consequences of atherosclerosis may extend into the coronary microcirculation. The investigators will evaluate three parameters of myocardial quantification with contrast Stress echocardiography and correlate with HbA1C levels.
Interventions
DRUGMetformin
Metformin 850mg
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
University of Sao Paulo General Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Type 2 diabetes mellitus * Normal echocardiogram * Absence of obstructive epicardial coronary disease
Exclusion criteria
* Obstructive coronary disease * Heart valve disease * COPD * Cardiac Arrhythmias * Cardiomyopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| myocardial blood flow velocity, myocardial blood flow reserve | 3 months |
Outcome results
None listed