Type 2 Diabetes
Conditions
Keywords
GPR 119, GLP-1 secretion, 2-oleoyl-glycerol, Dietary supplementation
Brief summary
The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.
Detailed description
We have found a new ligand for the GPR 119 receptor. This study evaluate the impact of this ligand on the incretion hormone responses, beta cell function and gall bladder function in healthy young men.
Interventions
DIETARY_SUPPLEMENTGPR 119 agonist, 2-oleyl glycerol
Emulgation, 50 ml. containing 2g 2OG
DIETARY_SUPPLEMENTOleic acid
Emulgation, 50 ml. containing 1.54g of oleic acid
DIETARY_SUPPLEMENTVehicle
Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol
Sponsors
University of Copenhagen
Glostrup University Hospital, Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy caucasians v- Normal OGTT (75 g of glucose) according to WHO's criteria * Normal hemoglobin * Informed consent
Exclusion criteria
* Liver disease (ALAT\> 2x normal level) * Nephropathy (s-creatinin \>130 microM or albuminuria) * Relatives with type 2 diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of this newly discovered GPR 119 agonist on gut hormone responses, in particular GLP-1 in response of the different meals administered to the subjects | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Glucose homeostasis, gall bladder contraction in response of the different meals administered to the subjects | 1 year |
Countries
Denmark
Outcome results
None listed