Sympathetic Nervous System
Conditions
Keywords
Xenon Anesthesia, LENOXe™ (xénon 100 % v/v) anesthesia, Muscle Sympathetic Activity, Baroreflex reagibility
Brief summary
The purpose of this study is to test the hypothesis that sympathetic neural outflow to muscles as well as a sympathetic baroreflexes are not altered during xenon anesthesia in Healthy Volunteers.
Detailed description
Objectives for this study : * Main Objective : Influence of Xenon anesthesia on Sympathetic Nervous Activity * Secondary Objectives : Security under LENOXe™ (xénon 100 % v/v) anesthesia
Interventions
DRUGxenon
Inhalational gas; dose allowed max.70 Vol.% in 30 % oxygen; the duration of the treatment will be to 30 minutes
Sponsors
Air Liquide Santé International
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Healthy volunteers \> 18 years and \< 65 years of age * ASA physical status I * Legal competence * for whom the consent form has been signed
Exclusion criteria
* Healthy volunteers \< 18 years and \> 65 years of age * Pregnancy, lactation period or missing secure anticonvulsive therapy * Missing legal competence * Participation in other clinical trials * Contraindications as mentioned on §4.3 of the SPCs of LENOXe™ (xénon 100 % v/v) * Any medication especially of Sildenafil (Viagra®) or other potency remedy * Existing relationship of dependency to the sponsor or the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle Sympathetic Activity (MSA)and Baroreflex reagibility under Xenon Anesthesia in comparison to awake | 30 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Arterial blood pressure, Heart frequency, Arterial O2 and CO2 Saturation,Skin conductance,Concentration of plasma catecholamines, Angiotensin & Renin under Xenon Anesthesia in comparison to awake | In continuous during 30 minutes |
Countries
Germany
Outcome results
None listed