Multicenter Cross Sectional Study of Primary Intestine Lymphoma

Multicenter Cross Sectional Study of Primary Intestine Lymphoma: Treatment Outcome and Quality of Life

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01043302

Enrollment

545

Registered

2010-01-06

Start date

2008-09-30

Completion date

2010-03-31

Last updated

2010-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-Hodgkin Lymphoma of Intestine

Keywords

lymphoma, intestine, outcome, quality of life

Brief summary

The purpose of this study is to determine whether whether surgical resection followed by chemotherapy is superior to systemic chemotherapy alone in terms of treatment outcome and quality of life (QOL) in patients with primary intestinal lymphoma.

Detailed description

Intestine is the one of commonly involved extranodal sites of non-Hodgkin's lymphoma (NHL). Thus, small and large Intestine account for approximately 30-40% of primary gastrointestinal tract lymphoma. More than 70% of intestinal lymphoma presents as localized disease, and surgery such as bowel resection is performed in many patients with intestinal lymphoma for diagnosis and treatment. However, it is still unclear whether surgical resection followed by chemotherapy is superior to systemic chemotherapy alone in terms of treatment outcome and quality of life (QOL). Thus, we analyze the clinical features and treatment outcome of patients with NHL of intestine, and at the same time perform a multicenter cross-sectional study about the QOL in survivors of intestine NHL. We evaluates the treatment outcomes of patients with intestine NHL from hospitals affiliated with the Consortium for Improving Survival of Lymphoma (CISL) in Korea. We assess the QOL of survivors who completed their treatment using the EORTC QLQ-C30 questionnaire.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

15 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Primary intestine lymphoma. Definition of primary intestine lymphoma: 1. Dominant site should be small and large intestine with or without regional lymph node involvement 2. Distant lymph node involvement can be allowed if the intestine lesion is the presenting site 3. Contiguous involvement of other organs such as liver, spleen can be allowed

Exclusion criteria

* Intestine involvement as a dissemination process in stage IV nodal lymphoma

Design outcomes

Primary

Measure	Time frame
Overall survival	Study entry

Secondary

Measure	Time frame
Quality of life	Study entry

Countries

South Korea

Outcome results