Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects

Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects: Longitudinal Multicentric Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01042834

Acronym

POLLAIR

Enrollment

Registered

2010-01-06

Start date

2008-02-29

Completion date

2010-07-31

Last updated

2011-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

air pollution, autonomic nervous system, sleep apnea, Heart rate variability, Healthy volunteers

Brief summary

Impact of air pollution on the autonomic nervous system activity and presence of sleep apnea in older subjects.

Detailed description

The relation between the air pollution and morbidity, cardiovascular mortality was increasing interest. Analyses show an increase of respiratory difficulty, but also cardiac deaths in the daytime when the atmospheric pollution was increased. It was demonstrated that health effects of ambient air pollution in subjects presenting cardiac or lung difficulty were important. Mechanisms show a possible relation to autonomic nervous system (ANS) deactivation and mortality. Particularly, the ageing and ANS reach would be more predictive of cardiovascular events. Thus, we suggest estimating in 60 healthy volunteers from 60 to 80 years old, the impact of the air pollution on the autonomic nervous system activity and sleep apnea consequences.

Interventions

OTHERAir pollution study on healthy volunteers.

The subjects are examined three times: * First the volunteers get used to equipments. * Second and third the volunteers sleep in a pollution or purified air.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* reside in Lyon and Saint-Etienne cities * security social affiliated or beneficiary * information note signed

Exclusion criteria

* heart rate disorders * pacemaker * tabacco addiction or second-hand smoke * morbid obesity (BMI \> 30) * insulin-dependent diabetes * chronic disease on treatment * antiarrythmic treatments

Design outcomes

Primary

Measure	Time frame
Frequency analysis of heart rate variability	inclusion, 1 test night and 2 experimental nights

Secondary

Measure	Time frame
Analysis of sleep, diurnal somnolence, sleep latency and PRS impact on the life quality.	1 test night and 2 experimental nights
Hour index quantification of night respiratory events.	1 test night and 2 experimental nights
Hour index quantification of autonomic awakening during the sleep.	1 test night and 2 experimental nights

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026