Agouti-related Peptide (AgRP) in Healthy Mothers and Mothers With Preeclampsia and Their Offspring

Genotype-phenotype Associations of Agouti-related Peptide (AgRP) in Postpartum Period in Preeclamptic and Non-preeclamptic Women and Their Offspring

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01042210

Enrollment

Registered

2010-01-05

Start date

2005-01-31

Completion date

2006-12-31

Last updated

2010-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia

Keywords

preeclampsia, agouti-related peptide, intrauterine growth, birth weight, Intrauterine growth restriction due to preeclampsia

Brief summary

The study is focused on the investigation of possible associations between plasma/serum levels of agouti related peptide (AgRP) and its genetic background in healthy women with physiological pregnancy (non-preeclamptic) and women with preeclampsia, in the postpartum period, and in their offspring.

Detailed description

The study is focused on investigation of possible genotype-phenotype interactions of agouti-related peptide (AgRP) in postpartum non-preeclamptic women and preeclamptic women and in their offspring.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

* For preeclampsia: * development of hypertension after the 20th week of pregnancy (systolic blood pressure, ≥140 mmHg; and/or diastolic blood pressure, ≥90 mmHg; measured at rest on two consecutive occasions at least 24 h apart) in previously normotensive women, and the onset of proteinuria (\>300 mg of urinary protein/L over 24 h) * single-fetus pregnancy * age range 18-35 y * no preconceptional history of hypertension * For mother with physiological pregnancies: * uncomplicated * spontaneous conception * single-fetus pregnancy * age range 18-35 y * spontaneous uncomplicated delivery * no history of preconceptional hypertension

Exclusion criteria

* For preeclampsia: * multiple pregnancy * preeclampsia superimposed to chronic hypertension preceding pregnancy * kidney disease * fetal malformations * For mothers with physiological pregnancies: * in vitro fertilization * fetal malformations * multiple pregnancy * events of bleeding

Design outcomes

Primary

Measure	Time frame
plasma/serum level of agouti/related peptide in peripheral blood in postpartum mother	2-4 hours postpartum
Plasma level of agouti-related peptide in umbilical cord blood from the newborn	immediately postpartum

Secondary

Measure	Time frame
maternal weight gain during pregnancy	using postpartum and peripartum data
birth weight of the newborn	immediately postpartum
maternal preconceptional BMI	anamnestic information

Countries

Czechia

Outcome results