Endotracheal Intubation, Patients Who Are Intubated for General Anesthesia
Conditions
Keywords
patients who are intubated for general anesthesia
Brief summary
The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.
Interventions
DRUGlabetalol
0.4 mg/kg labetalol intravenously 4 min before intubation
DRUGnicardipine
20 ㎍/kg nicardipine intravenously 4 min before intubation
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for general anesthesia with endotracheal intubation
Exclusion criteria
* Patients with heart failure or coronary artery disease 2-3 degree atrio-ventricular block or severe bradycardia (\< 45 beats/min) asthma, bronchial spasm or chronic obstructive pulmonary disease patients with anticipated difficult intubation (Mallampati class III, IV) severe hepatic or renal dysfunction allergy or contraindication to study medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hemodynamic variables (systolic blood pressure, diastolic blood pressure and mean blood pressure, heart rate) | preinduction- 10 min after intubation |
Countries
South Korea
Contacts
Primary ContactJung-Hee Ryu, Ph.D
Outcome results
None listed