Gut Oxygenation and Laparoscopy

GUT OXYGENATION DURING AND AFTER LAPAROSCOPIC AND OPEN COLON RESECTION. A RANDOMIZAD CLINICAL TRIAL

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01040013

Enrollment

Registered

2009-12-25

Start date

2008-03-31

Completion date

2009-09-30

Last updated

2009-12-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemia-Reperfusion Injury, Laparoscopy, Laparotomy, Oxygenation,

Keywords

LAPAROSCOPY,, LAPAROTOMY,, OXYGENATION,, ISCHEMIA-REPERFUSION INJURY

Brief summary

Patients with left-colon cancer will be randomized to laparoscopic or laparotomic operation. during surgery and for 6 days after operation, intestinal oxygen tension and ischemia-reperfusion injury markers will be evaluated to understand if pneumoperitoneum is associated with reduced splanchnic blood flow and ischemia-reperfusion injury.

Interventions

PROCEDURELaparoscopy

Laparoscopic Left-Colectomy

PROCEDUREleft colectomy by laparotomy

PatientS will be operated by laparotomy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Proven Cleft Colon Cancer, Signed Informed Consent

Exclusion criteria

* Emergency surgery, * Cancer infiltrating adjacent organ (at CT scan), * Severe cardiovascular (New York Heart Association class \> 3 ), * Respiratory (arterial PO2 \< 70 mmHg), * Renal (plasma creatinine \> 3 MG/dL) or hepatic (Child C) dysfunction

Design outcomes

Primary

Measure	Time frame
Intestinal oxygenation	7 DAYS

Secondary

Measure	Time frame
Ischemic reperfusion injury	7 DAYS

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 30, 2026