Genetic Basis of Odor Discrimination

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01039935

Enrollment

512

Registered

2009-12-25

Start date

2009-11-30

Completion date

2012-08-31

Last updated

2012-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-smokers

Keywords

Odor Discrimination

Brief summary

Prior to the main study we will perform a pilot study on 60 subjects. The purpose of the pilot study is to identify the range of odor concentrations that will be used in the main study and to optimize the tasks performed in the main study.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

1. Age 18-50 2. Current non-smokers

Exclusion criteria

1. Current smokers 2. Allergy to fragrances or smells of any kind 3. Active head cold, upper respiratory infection, or seasonal nasal allergies 4. History of nasal health problems, including endoscopic nasal surgery for sinus conditions or polyp removal. 5. Pre-existing medical condition that has caused anosmia or near total loss of the sense of smell, such as: head injury, cancer therapy, radiation to head and neck, or alcoholism

Design outcomes

Primary

Measure	Time frame
Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors	3 years

Secondary

Measure	Time frame
concentration at which odors need to be added to allow for discrimination; thresholds to all six odors; verbal descriptors assigned to all six odors	3 years

Countries

United States

Outcome results