Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy

Preoperative Vitamin D Levels as a Prognostic Factor for Postoperative Hypocalcemia and Hypoparathyroidism After Total Thyroidectomy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01039714

Enrollment

200

Registered

2009-12-25

Start date

2009-12-31

Completion date

2010-05-31

Last updated

2009-12-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypocalcemia, Hypoparathyroidism, Thyroidectomy, Vitamin D Deficiency

Keywords

Hypocalcemia, Hypoparathyroidism, Vitamin D deficiency, Total thyroidectomy, calcium, PTH

Brief summary

Hypocalcemia is one of the most frequent complications of total thyroidectomy, a procedure used for benign as well as malignant conditions of the thyroid gland. Postoperative hypocalcemia is usually caused by hypoparathyroidism. Vitamin D is implicated in calcium metabolism as it increases intestinal calcium transport and regulates parathormone production. Aim of the present study is to evaluate preoperative vitamin D levels as a prognostic factor for postoperative hypocalcemia and hypoparathyroidism.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patient is over 18 years old 2. Patient scheduled for total thyroidectomy 3. Patient signs and dates a written informed consent form (ICF) and indicates an understanding of the study procedures

Exclusion criteria

1. Primary hyperparathyroidism 2. Primary hypoparathyroidism 3. Chronic Renal Failure 4. Hypoalbuminemia 5. Neck irradiation 6. Systematic Diseases (e.g., infections) 7. Thyroid or parathyroid cancer 8. Osteoporosis 9. Drugs that influence calcium metabolism (vitamin D analogues, oral calcium supplements, biphosphonates, teriparatide, thiazide diuretics)

Design outcomes

Primary

Measure	Time frame
Impact of preoperative vitamin D levels on postoperative hypocalcemia after total thyroidectomy.	24 hours postoperatively

Secondary

Measure	Time frame
Impact of preoperative vitamin D levels on parathyroid function after total thyroidectomy.	24 hours postoperatively

Countries

Greece

Contacts

Primary ContactTheodossis S Papavramidis, MD, PhD

papavramidis@hotmail.com00302310993197

Backup ContactOlympia E Anastasiou, MD

olympia_anastasiou@yahoo.com00302310993197

Outcome results