Aging, Alzheimer's Disease
Conditions
Keywords
Healthy Aging
Brief summary
The purpose of this study is to gain a better understanding of the effects of exercise and cognitive training on improving brain function in healthy older adults who may be at risk for developing Alzheimer's Disease.
Interventions
OTHERExercise Training
Aerobic exercise training program designed by the Cardiac Rehabilitation department
OTHERCognitive Training
Based on cognitive training program Brain Fitness®
OTHERFlexibility Training
Non-aerobic flexibility training program designed by the Cardiac Rehabilitation department
OTHEREducational Sessions
DVD-based educational programs on history, art, and literature
Sponsors
National Institutes of Health (NIH)
The Cleveland Clinic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* First or Second-degree relative of someone with Alzheimer's Disease * Not currently engaging in regular exercise * Able to undergo an MRI * Fluent in English
Exclusion criteria
* Neurological illnesses/conditions * Medical illness/conditions that may affect brain function * Any unstable or severe cardiovascular disease or asthmatic condition * Severe depressive symptoms * Inability to walk unassisted
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain activation patterns measured by functional MRI | baseline and 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychological Testing | baseline and 12 weeks |
| Exercise assessment | baseline and 12 weeks |
Countries
United States
Outcome results
None listed