Cognitive Dysfunction
Conditions
Keywords
Cognition, subarachnoid hemorrhage.
Brief summary
This is a longitudinal, multi-center, prospective study of aneurysmal subarachnoid haemorrhage patients in neurosurgical units in Hong Kong.
Detailed description
The investigators aim to recruit a total of 240 aneurysmal subarachnoid haemorrhage patients. The schedule for neuropsychological and functional assessments will be phased in at the second to third week, the third month, and the twelve months after the initial haemorrhage.
Interventions
OTHERCognitive assessment
Cognitive and functional assessments at 2-4 weeks, 3 months and 12 months.
Sponsors
Chinese University of Hong Kong
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. Spontaneous subarachnoid haemorrhage with intracranial aneurysms as aetiology 2. Admission within 96 hours of ictus 3. Aged between 21 and 75 years 4. A speaker of Chinese (Mandarin or Cantonese) 5. Informed consent from patients or their legally acceptable representatives
Exclusion criteria
1. History of previous cerebrovascular disease or neurological disease other than intracranial aneurysm 2. History of neurosurgical operation prior to ictus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive dysfunction | 3 and 12 months | Montreal Cognitive Assessment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neurological Outcome | 3 and 12 months | Modified Rankin Scale |
| Generic Quality of Life | 3 and 12 months | ShortForm36(SF-36) |
| Activity of Daily Living | 3 and 12 months | Barthel Index |
| Disease-specific Quality of Life | 3 and 12 months | Stroke-specific-QOL |
| Functional Outcome | 3 and 12 months | Functional Independent Measure (FIM) |
Countries
China
Outcome results
None listed