Diabetes, Fatty Liver, Insulin Resistance, Obesity
Conditions
Keywords
Obesity, Diabetes, Insulin resistance, Fatty liver, NAFLD, Steatosis, Dietary fatty acids
Brief summary
The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects
Detailed description
Specific goals: 1. Investigate if substituting saturated fats with polyunsaturated fats reduces steatosis and improves hepatic and/or peripheral insulin action in abdominally obese subjects with type 2 diabetes 2. Investigate if changes of lipogenic enzymes in response to dietary fat intervention are associated with changes in hepatic/peripheral insulin sensitivity or liver fat content 3. Investigate potential mechanism of the effects of dietary fatty acids; e.g. gene expression and lipogenic enzyme activity
Interventions
Sponsors
Swedish Council for Working Life and Social Research
Uppsala University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* abdominal obese subjects with or without type 2 diabetes * sagittal abdominal diameter \>25cm
Exclusion criteria
* insulin treatment * history of serious cardiovascular events * morbid obesity * claustrophobia (relative criterion)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hepatic steatosis by MRT | 10 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Insulin resistance by oral glucose tolerance test | 10 weeks |
| Changes in adipose tissue gene expression and lipogenic enzyme activity | 10 weeks |
Countries
Sweden
Outcome results
None listed