Type 2 Diabetes
Conditions
Keywords
Type 2 diabetes, Diabetic dyslipidemia, VLDL-TG kinetics, VLDL-TG metabolism
Brief summary
Type 2 diabetes is associated with diabetic dyslipidemia, which is a major risk factor for coronary heart disease. Triglycerides (TG) and cholesterol are transported in the system of lipoproteins, and the metabolism of these lipids in plasma is closely interrelated. Evidence suggests that increased concentration of very low-density lipoprotein triglyceride (VLDL-TG) is a central pathophysiological feature of the lipid and lipoprotein abnormalities in diabetic dyslipidemia. The objective of this study was to investigate VLDL-TG kinetics and aspects of peripheral VLDL-TG metabolism, i.e. to what extent VLDL-TG associated fatty acids (FA) are oxidized or deposited in regional adipose tissue, in subjects with type 2 diabetes and healthy controls in the postabsorptive state and during acute hyperinsulinemia using ex-vivo labeled VLDL-TG tracers.
Interventions
Hyperinsulinemic euglycemic glucose clamp, duration 5 hours, plasma glucose 5 mmol/l, insulin dosage 1,0 mU•kg FFM/min, human insulin (Actrapid; Novo Nordisk A/S).
Sponsors
The Danish Medical Research Council
The Novo Nordic Foundation
The Danish Diabetes Association
University of Aarhus
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
20 Years to 65 Years
Healthy volunteers
Yes
Exclusion criteria
* Known disease except type 2 diabetes (type 2 diabetic subjects) * Smoking * Alcohol abuse * Prescription medication expect oral antidiabetics (type 2 diabetic subjects)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VLDL-TG production and clearance rates | — |
Secondary
| Measure | Time frame |
|---|---|
| VLDL-TG oxidation | — |
| VLDL-TG subcutaneous adipose tissue storage | — |
Countries
Denmark
Outcome results
None listed