Obesity
Conditions
Keywords
Obesity, Acute exercise, Intensity of exercise, Energy balance regulation, Appetite
Brief summary
Physical activity is mainly considered and use for its impact on energy expenditure in the treatment of obesity, and less is known concerning its indirect effects on energy intake. The aim of this work is to clarify the impact of an acute bout of exercise, depending on its intensity (high versus low), on the following energy intake and nutrient utilization, in obese and non-obese boys and men.
Detailed description
20 adolescent boys (10 obese and 10 leans) and 20 men (10 obese and 10 lean) will complete a sub-maximal test on a ergo cycle to draw their linear relationship between VO2 and Fc. Then they will enter a metabolic chamber three times, for 24 hours each. A first session will be considered as sedentary, and volunteers will remain inactive. During the second and third session, they will have to complete a cycling test generating an energy expenditure of 400 Kcal, once at low intensity (40%VO2max) and once at high intensity (70% VO2max). Those three sessions will be realized in a randomized order with an interval of at least 7 days and urinary collection over the 24hours will be done during all the sessions. At the beginning of the protocol, blood samples will be taken, body composition assessed by DXA and adiposity location evaluated by MNR.
Interventions
OTHERmetabolic chamber
20 adolescent boys (10 obese and 10 leans) and 20 men (10 obese and 10 lean) will complete a sub-maximal test on a ergo cycle to draw their linear relationship between VO2 and Fc. Then they will enter a metabolic chamber three times, for 24 hours each
Sponsors
Regional Program for Clinical Research 2009 (PHRC 2009)
Thermal Institution of Brides les Bains (FRANCE)
University Hospital, Clermont-Ferrand
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * Adults between 18 to 30 years old and adolescents between 12 and 15 years old * Body mass index : * lean adults : 20 \<BMI\< 25 kg.m² * obese adults : 30\<BMI\<38 kg.m² * lean adolescents: BMI \<90th percentile * obese adolescents: BMI\>97th percentile * Affiliated to National Health Insurance * Subject giving his written informed consent * Subject considered as normal after clinical examination and medical questionnaire.
Exclusion criteria
* Chronic pathologies : cardiovascular diseases, cancer, chronic inflammation diseases, renal, intestinal impairments * Refusal to be registered on the National Volunteers Data file * Being in exclusion on the National Volunteers Data file * Practising intensive physical exercise * Heavy consumer of alcohol or/and tobacco * Previous medical and/or surgery judged by the investigator as incompatible with this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of energy intake over the 24 hours is the primary outcome. It will be assessed during the 3 experimental conditions: sedentary, low intensive exercise, high intensive exercise | over the 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| Appetite feeling and substrate utilization are the two second outcomes. It will be assessed during the 3 experimental conditions: sedentary, low intensive exercise, high intensive exercise | with an interval of at least 7 days |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed