Trial in Cardiac Resynchronization Therapy (CRT): Right Ventricular Apex Versus High Posterior Septum

Echocardiographic Dyssynchrony in Heart Failure in CRT; Right Ventricular Apex v.s. High Posterior Septum

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01035489

Enrollment

Registered

2009-12-18

Start date

2009-01-31

Completion date

2012-06-30

Last updated

2011-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Keywords

Pacemaker treatment in heart failure, Cardiac resynchronization therapy, DDD pacemakers

Brief summary

In heart failure patients we hypothesised that right ventricular high posterior septum is superior to right ventricular apex in CRT and DDD pacemaker. In two separate trials we prospectively randomized the right ventricular lead placement to find evidence of differences in heart failure symptoms (NYHA-class), 6 minute hall walk and echocardiographic measurements of reverse remodelling and dyssynchrony.

Interventions

DEVICECRT in heart failure; Right ventricular apex v.s. high posterior septum

RV lead is randomized to either apex or high posterior septum

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* CRT: * LVEF \< 35% * LVEDD \> 5.5 cm * NYHA 3-4 * QRS \> 120 ms * Optimal medical treatment * Both CRT-pacemakers (CRT-P) and CRT combined with ICD (CRT-D)

Exclusion criteria

* Not fulfilling inclusion criteria or not written consensus

Design outcomes

Primary

Measure	Time frame
Echocardiographic reverse remodelling and dyssynchrony	3, 6, 12, 18 and 24 months

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 27, 2026