Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea
Conditions
Brief summary
Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise testing in patients with OSA. The investigators hypothesis is that patients with overlap syndrome will have a greater improvement in their cardiopulmonary exercise testing besides a possible improvement in their lung function test and airway resistance.
Detailed description
Patients presenting to the Oklahoma City VA sleep clinic with obstructive sleep apnea syndrome and a desire to initiate CPAP treatment will be included if they have overlap syndrome. Patients will undergo a spirometry and CPET before being started on CPAP as part of standard clinical care. The CPET will be repeated after 8-12 weeks of CPAP use. Patients will be excluded if they have any contraindication to mild exercise or they cannot perform an exercise test due to limited mobility.
Interventions
DIAGNOSTIC_TESTCPET
CPET will be done on patients with overlap syndrome before and after clinical CPAP treatment.
Sponsors
University of Oklahoma
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Obstructive sleep apnea (OSA) * COPD
Exclusion criteria
* Inability to perform exercise test due to musculoskeletal limitation * Cardiac condition preventing patient from mild exercise * Continuous oxygen supplement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of nasal CPAP on CPET performance in patients with overlap syndrome | 2 years |
Countries
United States
Outcome results
None listed