Myoma
Conditions
Brief summary
Arterial and venous thrombotic events are the clinical manifestation of postoperative hypercoagulability. Altered serum magnesium may play a role in the balance of coagulation. In this study, the investigators investigated the effect of magnesium sulphate on the postoperative coagulation change in total intravenous anesthesia (TIVA).
Interventions
DRUGMagnesium Sulfate
Group M received 50 mg/kg of magnesium sulphate on 100 ml of isotonic saline over 10 minutes during the anesthesia induction, followed by the 15 mg/kg/h by continuous infusion during the operation
DRUGnormal saline
Group S received the same volume of isotonic saline as same method.
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ASA Ⅰ-Ⅱ patients undergoing pelviscopic gynecologic operation under general anesthesia.
Exclusion criteria
* Pregnancy * Previous known hematologic disorder * Recent medication interfering with hemostasis * Severe anemia * Liver disease * Cardiovascular or respiratory disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| thromboelastography (TEG) analysis | twice | 1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| hemoglobin level | twice | 1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia |
| platelet count | twice | 1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia |
| international normalized ratio of prothrombin time (INR-PT) | twice | 1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia |
| activated partial thromboplastin time (aPTT) | tiwce | 1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia |
| serum magnesium level | twice | 1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia |
Countries
South Korea
Outcome results
None listed