Intra-uterine Injection of Human Chorionic Gonadotrophin (hCG) Before Embryo Transfer

Intra-uterine Injection of Human Chorionic Gonadotrophin Before Embryo Transfer in ICSI

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01030393

Enrollment

472

Registered

2009-12-11

Start date

2010-01-31

Completion date

2011-02-28

Last updated

2012-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

hCG, pregnancy, implantation, ICSI, IVF

Brief summary

Chorionic gonadotrophins (hCG) play an important role in implantation. The aim of the study is to evaluate the effect of intrauterine injection of hCG before embryo transfer in IVF/ICSI on the implantation and pregnancy rates. The rational is that intrauterine hCG injection will attract regulatory T cells and improve implantation.

Detailed description

Background : Human chorionic gonadotrophin ( hCG) was found to secreted immediately after fertilization by the embryo. It plays an important role in implantation and in attracting regulatory T cells to the endometrium. Rational : Intrauterine injection of hCG before embryo transfer in IVF/ICSI may increase endometrial regulatory T cells ( Treg ) and improve the implantation and pregnancy rates. Aim of the work : To study the effect of intrauterine injection of hCG before embryo transfer on the implantation and pregnancy rates after IVF/ICSI. Subjects : Infertile patients undergoing ICSI. Inclusion criteria : * Female age less than 40 years * Male factor infertility * Normal female hormonal profile and uterine cavity Exclusion criteria : * Previous ICSI failure * Azoospermia * Endometriosis Study group: Intrauterine injection of 100 iu of hCG (group 1)or 200 iu of hCG ( group 2) will be done during the dummy embryo transfer which is done 10-15 minutes before the actual embryo transfer. Control group: The embryo transfer will be done without prior intrauterine injection of hCG Main outcome measures : Implantation and pregnancy rates Secondary outcome measures : miscarriage and delivery rates

Interventions

DRUGhuman chorionic gonadotrophin

intrauterine injection of 100 iu (group1) or 200 iu (group2) of hCG before embryo transfer in IVF/ICSI And intrauterine injection of 500 iu hCG before embryo transfer .

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 39 Years

Healthy volunteers

Inclusion criteria

* male factor infertility * normal female hormonal profile * normal uterine cavity

Exclusion criteria

* previous ICSI failure * endometriosis * azoospermia

Design outcomes

Primary

Measure	Time frame
implantation and pregnancy rates	5 weeks after embryo transfer

Secondary

Measure	Time frame
miscarriage and delivery rates	9 months from embryo transfer

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026