Pilot Study of Organic Nitrates on Endothelial Function in CAD Patients

Pilot Study of Organic Nitrates on Endothelial Progenitor Cells and Endothelial Function in Patients With Coronary Artery Disease

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01030367

Acronym

ONEEF

Enrollment

Registered

2009-12-11

Start date

2007-01-31

Completion date

2010-01-31

Last updated

2009-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

Coronary artery disease

Brief summary

Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54). Here, we want to test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function.

Detailed description

In this pilot study we test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function. These parameters will be measured before and after 14d of treatment.

Interventions

DRUGPETN, ISDN

Oral dosing of organic nitrates PETN 2x 80mg per day ISDN 2x40mg per day

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Coronary artery disease, 2- or 3-vessel disease

Exclusion criteria

* Acute myocardial infarction, acute heart failure, cancer, acute infections

Design outcomes

Primary

Measure	Time frame
Endothelial function Number of endothelial progenitor cells Function of endothelial progenitor cells	Baseline and after 14d

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 29, 2026