Obesity, Sleep
Conditions
Keywords
sleep, obesity, children, eating behaviors, activity, leptin, ghrelin
Brief summary
The purpose of the proposed study is to determine whether the amount children sleep is associated with changes in hormones, hunger, motivation to eat, and food intake. Fifty children 8-11 years old who sleep 9-10 hours per night will be enrolled for a 3-week study. For 1 week each, children will be asked to sleep their typical amount, increase their sleep by 1-½ hours, and decrease their sleep by 1-½ hours. Half of the children will be asked to increase their sleep first and half to decrease their sleep first. During each week, the following will be gathered: sleep duration (measured by actigraphy, which is a small device that measures sleep), levels of hormones measured through blood draws, self-reported hunger and appetite, food intake (measured by 3 days of 24-hour recall), how motivated children are to eat (measured using a computer activity), and child height and weight. We believe that when children sleep less they will show changes in hormones associated with hunger and appetite, report being hungrier, be more motivated to eat, and eat more food.
Interventions
BEHAVIORALIncrease Sleep
Children are asked to increase their sleep by approximately 1 1/2 hours/night for 1 week.
BEHAVIORALDecrease Sleep
Children are asked to decrease their sleep by approximately 1 1/2 hours/night.
Sponsors
American Diabetes Association
The Miriam Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
8 Years to 11 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 8-11 years old * BMI for age and gender \> 5th percentile (but no greater than 100% overweight) * Sleep approximately 9-10 hours nightly * Attend elementary school * Like at least 1 food and 1 activity used in the reinforcement paradigm * Able to understand and complete the reinforcement paradigm
Exclusion criteria
* Existence of a diagnosable sleep disorder * Medical or psychiatric condition that could influence sleep or weight * Onset of menarche * Inability to complete study materials, including diagnosed disabilities * Dietary restrictions/allergies to foods used in the study that preclude them from study participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| absolute reinforcing value of food as compared to sedentary activities | after 1 week of typical sleep duration, after 1 week of decreased sleep duration, after 1 week of increased sleep duration |
Secondary
| Measure | Time frame |
|---|---|
| plasma levels of leptin and ghrelin | after 1 week of typical sleep duration, after 1 week of decreased sleep duration, after 1 week of increased sleep duration |
| caloric intake | after 1 week of typical sleep duration, after 1 week of decreased sleep duration, after 1 week of increased sleep duration |
| levels of physical activity | after 1 week of typical sleep duration, after 1 week of decreased sleep duration, after 1 week of increased sleep duration |
| subjective ratings of hunger and appetite | after 1 week of typical sleep duration, after 1 week of decreased sleep duration, after 1 week of increased sleep duration |
Countries
United States
Outcome results
None listed