Pharmacogenetics of Propofol and Depth of Anesthesia

The Effect of Pharamocogenetices on Anesthesia Induction With Propofol

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01029379

Enrollment

100

Registered

2009-12-10

Start date

2010-01-31

Completion date

2013-02-28

Last updated

2013-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Propofol

Keywords

propofol, depth of anesthesia, pharmacogenetics, Depth of anesthesia in correlation to plasma concentrations of propofol

Brief summary

Propofol, (2,6-diisopropylphenol) is a short-acting anesthetic drug used for induction and maintenance of anesthesia. The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous EEG and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination. Our hypothesis is that there is an individual requirement of Propofol plasma concentration depending on genetic differences in drug elimination. 200 patients, ASA classification 1, planned for elective surgery of a duration of at least 30 minutes will be included in this study.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Healthy caucasian patents, * (ASAclassification 1) planned for elective surgery, * with body mass index 20-30, * free from analgetic drug \> 12 hours prior to anesthesia

Exclusion criteria

* Pregnancy, * Smoking, * allergy to propofol or peanuts, * alcohol abuse, * non-caucasian

Design outcomes

Primary

Measure	Time frame	Description
EEG pattern in correlation to clinical anesthesia	20120101	EEG pattern in correlation to clinical anesthesia

Countries

Sweden

Outcome results