Cerebrovascular Autoregulation During Sepsis

Dynamic Cerebrovascular Autoregulation During Sepsis and Sepsis-associated Delirium

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01029080

Enrollment

Registered

2009-12-09

Start date

2009-12-31

Completion date

2011-03-31

Last updated

2013-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium, Sepsis

Keywords

Brain, blood flow, Measurement techniques, flow velocity waveform analysis, Monitoring, intensive care, Sepsis, transcranial doppler ultrasound (TCD), Cerebrovascular autoregulation, sepsis-associated delir

Brief summary

The aim of the study is to correlate the dynamic cerebrovascular autoregulation by patients with sepsis with a sepsis-associated delirium.

Interventions

OTHERno interventions

No interventions

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* clinical symptoms of sepsis, severe sepsis and septic shock * possibility for measurement of transcranial doppler ultrasound * age over 18 years

Exclusion criteria

* preexisting cerebrovascular disease * preexisting immunological disease * traumatic brain injury * intracranial infectious disease * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Disturbed cerebrovascular autoregulation correlates with sepsis associated delir	1 year	The Index of autoregulation (Mx) was measured and correlated with the clinical incidence of a sepsis associated delir

Secondary

Measure	Time frame
Correlation between inflammatory parameters and disturbed cerebrovascular autoregulation	1 year
Correlation between inflammatory parameters and sepsis-associated delirium	1 year

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 25, 2026