Endothelial Function, Exercise Capacity, Heart Transplantation
Conditions
Keywords
Heart transplantation, Exercise capacity, Endothelial function
Brief summary
The purpose of this study is to investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively. Effect on the hormones and the immune system is evaluated using blood samples.
Detailed description
To investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively using forearm flow mediated dilatation. Effect on the blood natriuretic peptides and the inflammatory markers is evaluated using blood samples at baseline and after the training or control period.
Interventions
OTHERIntensive physical exercise
Intensive physical exercise 1 hour three times per week
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Heart transplant recipients \> 1 year after transplantation
Exclusion criteria
* Recent rejection, severe renal dysfunction, graft dysfunction, allograft vasculopathy, cancer, inability to exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in maximal oxygen uptake. | 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Change inm flow mediated vasodilatation. | 8 weeks |
Outcome results
None listed