Antiemetic Efficacy and Safety of Dexamethasone in Obstetric Surgical Patients

Antiemetic Efficacy and Safety of Dexamethasone in Patients Undergoing Caesarean Sections at Mulago Hospital

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01028547

Enrollment

250

Registered

2009-12-09

Start date

2010-01-31

Completion date

2010-03-31

Last updated

2010-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea and Vomiting

Keywords

PONV

Brief summary

This is a randomised controlled double blinded clinical trial to determine the antiemetic efficacy and safety of either 8 mg of dexamethasone or normal saline (placebo) given 1 hour before induction of either spinal or general anaesthesia in 2 arms (of 150 each).

Interventions

DRUGdexamethasone

single Bolus dose of dexamethasone 8mg

OTHERnormal saline

2 ml 0.9% saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* all woman above 18 years old presenting for obstetric surgery and have consented to study.

Exclusion criteria

* refusal/unable to consent, * younger than 18 years old, * hypertensive, * diabetic, * preeclamptic, * sepsis, * ASAIIIE plus.

Design outcomes

Primary

Measure	Time frame
presence of post nausea and or vomiting	24 hours

Secondary

Measure	Time frame
perianal itching	24 hours
hyperglycemia	24 hours
hypertension	24 hours

Countries

Uganda

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026