Methicillin-resistant Staphylococcus Aureus Infection
Conditions
Keywords
Preoperative screening, MRSA, Incidence, Postoperative infection, Preoperative MRSA Screening Incidence, Postoperative MRSA Infection Rate
Brief summary
The purpose of this study is to evaluate the prevalence of pre-surgical patients who are MRSA carriers. From an evidence-based practice perspective, findings from this study can be considered in the evaluation of the hospital SOP mandating pre-surgical MRSA screening requirements for patients with scheduled surgeries. The central hypothesis to be addressed in this study is whether the MRSA colonization and subsequent post-operative infection are the equivalent in these populations.
Detailed description
Design and Methods: Subjects in this study of 975 pre-operative, scheduled surgical patients are in one of the three following groups: * Group 1 (N=325): Allocation sample of surgical patients required to be MRSA screened per hospital SOP (including patients having a positive MRSA history, orthopedic surgery, undergoing dialysis, or transfer from another hospital, nursing home, skilled nursing facility, or jail). * Group 2 (N=650): Randomized sample (1:1 ratio) of surgical patients not required to be MRSA screened per hospital SOP, to one of the following two groups: * 2a (N=325): MRSA screening; or * 2b (N=325): No MRSA screening. All subjects were followed for 30 days post-operatively to determine the incidence of post-operative infection. Treatment, diagnostic, and hospitalization data were collected for patients diagnosed with post-operative infection.
Interventions
OTHERPreoperative MRSA screening
MRSA preoperative screening and post operative infection rate, 30 days post operative
Sponsors
Cardinal Health
Inova Health Care Services
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Pre-surgical out patient at ILH 2. Surgical procedure scheduled at least 2 days before surgery 3. Surgery being done at ILH operating room 4. Provision of signed ICF
Exclusion criteria
1. Patient 18 years of age or older who is deemed by the hospital incapable of providing Informed Consent 2. Inability to communicate in the English language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to compare the prevalence of MRSA colonization and its relationship to post-operative infection in patients who are currently pre-operatively MRSA screened per SOP to those who are not. | 30 days |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is to compare medical charges associated with diagnosis and treatment of post-operative infections for these groups using cost-effectiveness analysis. | 30 days |
Countries
United States
Outcome results
None listed