Tracheobronchitis
Conditions
Keywords
tracheobronchitis
Brief summary
Mechanically Ventilated patients in the intensive care unit (ICU) often present with fever, and purulent sputum, but without radiological evidence of pneumonia. These patients may have tracheobronchitis. Some suspect that this condition precedes the development of pneumonia. Antibiotic treatment in tracheobronchitis is controversial. The investigators will recruit patients with tracheobronchitis and randomize them into 2 groups. One group will be treated with antibiotics and the other group will serve as control.
Detailed description
Patients with proved tracheobronchitis who are mechanically ventilated for more than 48 hrs, will undergo a CT scan to rool our pneumonia that may not be seen on a routine chest x-ray. After ruling out pneumonia by CT scan, patients will be randomized into 2 groups. Intervention group will receive 7 days of treatment with Piperacillin/Tazobactam. A control group will receive nothing. Primary endpoint wil be the rate of new pneumonias and secondary endpoint will be ICU Length of stay, days on mechanical ventilation and 28 day mortality.
Interventions
DRUGPiperacillin/Tazobactam for 7 days
Piperacillin/Tazobactam for 7 days
Sponsors
Assaf-Harofeh Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Tracheobronchitis as defined by: * Purulent sputum with \> 10 x 4 CFU * Leukocytosis or leukopenia * Fever * No pneumonia on CT scan
Exclusion criteria
* Recent treatment of pneumonia * Abnormal Chest X-ray * Evidence of Pneumonia on CT scan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of development of new pneumonia | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| ICU length of stay (LOS) and mortality | 2 years |
Countries
Israel
Contacts
Primary ContactArie Soroksky, MD
Outcome results
None listed