A Comparison of Methods to Detect Polyps During Colonoscopy

Comparison of Detection of Polyps During Both Insertion and Withdrawal Phases of Colonoscopy Versus the Standard Practice of Detection of Polyps During the Withdrawal Phase of Colonoscopy: A Prospective Quality Improvement Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01025960

Enrollment

768

Registered

2009-12-04

Start date

2009-11-30

Completion date

2012-01-31

Last updated

2012-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

colonoscopy, adenoma detection, polyps

Brief summary

Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer deaths in western countries. Colonoscopy is a preferred colorectal screening modality since it has both diagnostic and therapeutic capability. Detection and removal of polyps at colonoscopy decreases the incidence and mortality from colorectal cancer. Typical practice is to insert the colonoscope rapidly until it reaches the cecum (a pouch-like portion of the intestines, where the large bowel and the small bowel meet). The physician then withdraws the colonoscope slowly and looks for any polyps or abnormalities within the large bowel. The purpose of this study is to compare this standard practice to the approach whereby the physician examines the bowel as the scope is initially inserted AND as the colonoscope is withdrawn from patients' colons.

Interventions

PROCEDUREStandard Inspection Colonoscopy

The large bowel will be inspected for polyps during the withdrawal of the colonoscope to the cecum, and during the withdrawal of the scope from the large bowel.

PROCEDUREDual Inspection Colonoscopy

The large bowel will be inspected for polyps during the insertion of the colonoscope to the cecum, and during the withdrawal of the scope from the large bowel.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Adult patients * Patients able to provide an informed consent * Patients undergoing colonoscopy

Exclusion criteria

* Pregnant women * Patients with Familial Adenomatous Polyposis Syndromes (FAP) * Patients with Hereditary Non-polyposis Colon Cancer Syndrome (HNPCC) * Patients who have undergone previous surgical resection of the colon * Patients who have been diagnosed with inflammatory bowel disease

Design outcomes

Primary

Measure	Time frame
Adenoma detection rates for each method	within the first 30 days after colonoscopy

Secondary

Measure	Time frame
Comparison of procedure times for each method	1 year
Percentage of patients with at least one adenoma detected by each method	1 year
Comparison of percentage of adenomas classified as high risk for each method	1 year

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 20, 2026