Combined Nutritional and Exercise Strategies to Reduce Liver Fat Content in Patients With Type 2 Diabetes

Conditions

Postprandial Lipids Metabolism, Type 2 Diabetes

Keywords

liver fat, postprandial lipids metabolism, diet, exercise, type 2 diabetes

Brief summary

The aim of this study will be to evaluate in patients with type 2 diabetes the effects on liver fat of an intervention with a diet relatively rich in CHO/rich in fibre/low GI or a diet rich in MUFA, either combined or not with a structured program of physical exercise, with emphasis on mechanisms possibly underlining these effects, namely changes in postprandial triglyceride-rich lipoproteins, body fat distribution, insulin sensitivity, oxidative stress and inflammation, adipose tissue lipolytic activities, aerobic capacity and endothelial function.

Lutgarda Bozzetto, Rita Polito, Ersilia Nigro, Anna Prinster, Giuseppe Della Pepa et al. (11 authors)

European Journal of Clinical Investigation2021-04-025 citations

10.1111/eci.13548

Reduction in liver fat by dietary MUFA in type 2 diabetes is helped by enhanced hepatic fat oxidation.

Bozzetto L, Costabile G, Luongo D, Naviglio D, Cicala V, Piantadosi C, Patti L, Cipriano P, Annuzzi G, Rivellese AA.

2016-09-2028 citations

10.1007/s00125-016-4110-5

A CHO/fibre diet reduces and a MUFA diet increases postprandial lipaemia in type 2 diabetes: no supplementary effects of low-volume physical training.

Bozzetto L, Annuzzi G, Costabile G, Costagliola L, Giorgini M, Alderisio A, Strazzullo A, Patti L, Cipriano P, Mangione A, Vitelli A, Vigorito C, Riccardi G, Rivellese AA.

2013-10-1721 citations

10.1007/s00592-013-0522-6

Interventions

OTHERRich in MUFA diet -PA

The patients will follow a rich in MUFA diet without a physical activity program.

OTHERhigh fiber/low glycemic index diet + pa

patients will follow for two months a high fibre/ low glycemic index diet with a physical activity program.

OTHERRich in MUFA diet+PA

Patients will follow for two months a rich in MUFA diet with a physical activity program.

OTHERHigh fibre/low glycemic index diet-PA

Patients will follow for two months a high fibre/low glycemic index diet without a physical activity program.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

35 Years to 65 Years

Healthy volunteers

No

Inclusion criteria

* Men and postmenopausal women * Age 35-65 years * BMI 27- 34 kg/m2 * HbA1c \<8% * Fasting plasma cholesterol \<250 mg/dl * Fasting plasma triglycerides \<300 mg/dl

Exclusion criteria

* Hypolipidemic drugs * Plasma creatinine \>1.7 mg/dl transaminases \> 2 norma values * Ischemic heart disease or positive treadmill stress test * High intensity regular physical activity * Any disease or chronic or/and acute condition contraindicating physical activity(anaemia, and infectious, neoplastic, neurological and osteoarticular diseases).

Design outcomes

Primary

Measure	Time frame
Liver fat content	0 and 8 weeks
postprandial lipids metabolism	0 and 8 weeks

Secondary

Measure	Time frame
changes in body fat distribution	0 and 8 weeks
oxidative stress and inflammation	0 and 8 weeks
adipose tissue lipolytic activities	0 and 8 weeks

Outcome results

None listed