Obesity
Conditions
Keywords
overweight
Brief summary
To assess the effect of inulin on appetite profile ratings, food intake and satiety hormones.
Detailed description
Based upon a slower digestion and the fermentation in the intestinal tract, food containing soluble dietary fibres, such as inulin, is hypothesized to be more satiating, and to limit energy intake, in humans. Does supplementation of inulin (at 2 dosages) versus placebo over 13 consecutive days in normal to overweight men and women, lead to an increase in satiety, a reduction in food intake and stronger postprandial increases in GLP-1 and PYY?
Interventions
DIETARY_SUPPLEMENTinulin
10gram/day inulin for 13-day treatment
DIETARY_SUPPLEMENTplacebo
16gram/day maltodextrin (placebo) for 13-day treatment
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* age between 18 and 60 years * BMI between 23 and 28 kg/m2 * dietary unrestraint (TFEQ: F1\<9)
Exclusion criteria
* age under 18 and above 60 years * BMI under 23 and above 28 kg/m2 * dietary restraint (TFEQ: F1\>9) * use of medication * pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| food intake | on testday 0 and 13 |
Secondary
| Measure | Time frame |
|---|---|
| appetite profile ratings | on test day 0, 8 and 13 (at 16 time points) |
| satiety hormones (GLP-1 and PYY) | on test day 0 and 13 (at 9 time points |
Countries
Netherlands
Outcome results
None listed