Single-nucleotide Polymorphism (SNP) for Glaucoma
Conditions
Keywords
SNP, single-nucleotide polymorphism, glaucoma, primary open angle glaucoma
Brief summary
A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.
Detailed description
Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.
Interventions
GENETICSNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
Sponsors
Korea Healthcare Technology R&D Project
Korea Advanced Institute of Science and Technology
Chungnam National University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of primary open angle glaucoma
Exclusion criteria
* Primary open angle glaucoma combined with congenital ocular disease * Primary open angel glaucoma combined with other ocular disease * Significant systemic disease other than systemic hypertension and diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| genotyping for the SNP associated with primary open angle glaucoma | one year |
Secondary
| Measure | Time frame |
|---|---|
| genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns | one year |
Countries
South Korea
Outcome results
None listed