Non-invasive Measurement of Hemoglobin in Retinal Arteries

Non- Invasive Measurement of the Absolute Hemoglobin Value in the Retinal Arteries of Anemic and Healthy Subjects Using a New Approach

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01025011

Enrollment

100

Registered

2009-12-03

Start date

2008-03-31

Completion date

2010-06-30

Last updated

2009-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anemia, Healthy Subjects

Keywords

retinal hemoglobin concentration, non-invasive hemoglobin measurement

Brief summary

The purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries.

Detailed description

To our knowledge no tool exists that allows for direct collection of hemoglobin data in the eye. In many eye diseases (especially diabetic and hypertensive retinopathy as well as in retinal vessel occlusions) retinal circulation is modified. Knowing hemoglobin concentration on the site of the pathology will give us further information about the pathogenesis of this diseases and may provide a new possibility in therapy. The purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries. Healthy volunteers from the eye clinic and pregnant otherwise healthy patients of the gynecological department of the Triemli Hospital, Zurich, as well as anemic gynecological patients that show up for a check-up are included. Hemoglobin will be quantified by a blood draw of a cubital vein. Using a Fundus Camera (Nidek AFC-230) pictures of the fundus will be taken from each study patient. Afterwards the study investigator selects a retinal artery of interest which will be used for measuring the hemoglobin concentration. Intensity of the green channel of the camera chip is determined with the aid of the law of Lambert-Beer. Absolute Hemoglobin concentration is calculated in relation to the vessel volume.

Interventions

DEVICEFundus photography, cubital blood draw

blood draw from a cubital vein to measure hemoglobin concentration taking a fundus photography with a Nidek AFC-230, no pupil dilation needed

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy volunteers * pregnant patients from the Triemli Hospital that came for a routine check up * anemic patients of the same dept with various gynecological tumors

Exclusion criteria

* any known retinal eye disease * poor fundus picture quality due to fixtion problems or too small pupil or media intransparency * not willing to participate in a study

Design outcomes

Primary

Measure	Time frame
Correlation of hemoglobin concentration measured in a cubital vein and in a non invasive way using hemoglobinometry in the retinal veins	2.5 years

Countries

Switzerland

Contacts

Primary ContactYves Robert, Prof MD

yves.robert@triemli.stzh.ch+41 44 466

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026