Insulin Sensitivity, Microcirculation
Conditions
Keywords
Angiotensin II
Brief summary
In this study we hypothesize infusion of Angiotensin II improves the insulin-induced microvascular dilatation and therefore insulin-mediated glucose uptake. Objectives: Does infusion of Angiotensin II increase insulin-mediated glucose uptake via enhanced insulin-mediated microvascular function in healthy subjects?
Interventions
DRUGAngiotensin II
Angiotensin II
DRUGPhenylephrine
Phenylephrine
DRUGPlacebo
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1.18-60 years 2.Caucasian 3.Blood pressure \<140/90 mmHg.
Exclusion criteria
1. Obesity (BMI\>27kg/m2) 2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA 4. Smoking 5. Alcohol use \>4U/day 6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs) 7. Pregnancy 8. Wearing contact lenses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| functional recruitment of capillaries in the skin | January 2009 |
Secondary
| Measure | Time frame |
|---|---|
| perfused capillary density in the nailfold | January 2009 |
| Endothelium- (in)dependent vasodilatation of finger skin microcirculation | January 2006 |
| Insulin sensitivity | January 2009 |
Countries
Netherlands
Outcome results
None listed