Central Corneal Thickness in Glaucoma

Central Corneal Thickness in Patients With Exfoliation Syndrome, Exfoliative Glaucoma, Exfoliative Glaucoma, Primary Open-angle Glaucoma and Ocular Hypertension

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01023997

Enrollment

700

Registered

2009-12-02

Start date

2008-01-31

Completion date

2013-01-31

Last updated

2014-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exfoliation Syndrome

Keywords

corneal thickness, exfoliation

Brief summary

The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate the value of corneal thickness in the diagnosis and management of glaucoma.

Detailed description

To compare the central corneal thickness measurement in patients with exfoliation, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate the value of corneal thickness in the diagnosis and management of glaucoma. Prospective study in progress. Randomly selected patients undergo a comprehensive ophthalmic exam which includes 2 separate pachymetry measurements in 2 different examinations at the same time of the day (10:00 am) with 3 different pachymeters. The values obtained are correlated with a number of other glaucoma parameters. A thinner cornea may represent a specific attribute and an additional risk factor for patients with exfoliation. Evaluation of corneal thickness is an important exam in the management of patients with exfoliation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

25 Years to 89 Years

Healthy volunteers

Yes

Inclusion criteria

* Exfoliation material on pupil * Intraocular pressure below 21 mm Hg without glaucomatous damage * Intraocular pressure above 21 mm Hg without glaucomatous damage * Raised intraocular pressure with glaucomatous damage

Exclusion criteria

* Corneal disorders * History of trauma * Evidence of corneal abnormality that may influence IOP * Contact lens use * Corneal surgery

Design outcomes

Primary

Measure	Time frame
central corneal thickness	Morning measurement (10:00-11:00)

Secondary

Measure	Time frame
Visual field, scanning laser polarimetry	10:00-11:00

Countries

Greece

Outcome results