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Increasing the Yield of Blood Cultures in Neonates

Increasing the Yield of Blood Cultures in the Neonatal Intensive Care Unit- A Prospective Controlled Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01023555
Enrollment
1500
Registered
2009-12-02
Start date
2010-01-31
Completion date
2010-07-31
Last updated
2011-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacteremia

Keywords

Bacteremia, Blood Cultures, Sepsis

Brief summary

The purpose of this study is to determine whether the use of a single blood sample of 1cc in an aerobic bottle will provide a better yield and time to positivity than 2 samples of 0.5 cc in 2 (aerobic and anaerobic) bottles for blood cultures in neonates.

Interventions

OTHER1cc of blood in a single aerobic culture bottle

The efficacy of using 1cc of blood in a single aerobic bottle for cultures in neonatal bacteremia will will be compared with the traditional 0.5cc of blood in 2 Bottles

Sponsors

Shaare Zedek Medical Center
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* All blood cultures taken in the NICU during the study period.

Exclusion criteria

* Bacteria that are normal flora of the skin such as Coagulase negative staphylococci or Streptococci Viridans are considered, except if grown in two sets of cultures or in the presence of laboratory and clinical indices of infection.

Design outcomes

Primary

MeasureTime frame
Non Inferiority of 1 cc blood culture in a single aerobic bottle instead of 0.5 cc for 2 bottles.6months

Secondary

MeasureTime frame
utility of the routine use of anaerobic bottle for blood cultures in newborns6 months
Comparison of time to positivity of 1 cc blood culture in a single aerobic bottle instead of 0.5 cc for 2 bottles (aerobic and anaerobic)6 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026