The Preemptive Analgetic Potency of Low Dose S-Ketamine

The Opioid Sparing Effect of Minimal Dose S-Ketamine Applied as a Coanalgesic During the Perioperative Period - An Active Placebo-Controlled, Double Blinded, Randomized Clinical Trial (МiniKet)

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01022840

Acronym

Miniket

Enrollment

Registered

2009-12-01

Start date

2009-02-28

Completion date

2012-09-30

Last updated

2012-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Brief summary

The primary hypothesis is improved postoperative analgetic quality using S-Ketamine, particularly in patients suffering from chronic pain.

Detailed description

The investigators are dealing mainly with the finding of the right dosage for the optimal safety and efficacy of S-Ketamine, but also discovering new possible areas of investigation (e.g. anti-depressive effect, anti-neuropathic effect).

Interventions

DRUGS-Ketamine

drug

OTHERPlacebo Comparison

saline control

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Scheduled for major abdominal surgery * Suitable for PCA * Cardio-vascular stable * Age: 18+ * Between 50-120kg BW * ASA 1-3 * Good Compliance for pain monitoring

Exclusion criteria

* Allergy to S-Ketamine * Severe liver or kidney dysfunction * Severe coronary disease * Pregnancy * Present or past psychotic disorders * Addiction to alcohol or opioids * Poor compliance

Design outcomes

Primary

Measure	Time frame
postoperative opioid consumption	1 year

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026