Atherosclerosis
Conditions
Keywords
atherosclerosis, vascular inflammation, LpPLA2, hsCRP, MCP-1, 18FDG-PET
Brief summary
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Various inflammatory markers such as LpPLA2,MCP-2 and hsCRP are well-known prognostic factors for the cardiovascular event. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between various inflammatory markers and vascular inflammation detected by 18FDG-PET.
Interventions
OTHERCross section study
This is not intervention study. The purpose of the study is to examine the relationship between various inflammatory markers and PET imaging at the cross section setting
Sponsors
Korea University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 88 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy patients for visiting routine medical check in our clinic
Exclusion criteria
* History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization) * Diabetes * Stage 2 hypertension (resting blood pressure, ≥160/100 mmHg) * Malignancy * Severe renal or hepatic disease * Subjects taking medications that might affect inflammation such as NSIAD and statin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET | 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between various inflammatory markers and atherosclerosis measured by carotid intima media thickness | 12 weeks |
Countries
South Korea
Outcome results
None listed