Hip Replacement, Hyperglycemia, Knee Replacement
Conditions
Keywords
knee replacement, hip replacement, hyperglycemia, diabetes, osteoarthritis
Brief summary
The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.
Detailed description
Postoperative infections remain one of the most frequent reasons of failure of hip and knee prostheses. Diabetes increases the risk of infections. In other fields of surgery, hyperglycemia induced by surgical stress (stress/perioperative hyperglycemia) has been associated with higher rates of postoperative infections and complications. Such studies have not yet been performed in the field of joint replacement surgery. Unlike several other risk factors of infected joint replacements, hyperglycemia is potentially modifiable and therefore its prevalence, predisposing factors and association with postoperative infections are of interest.
Interventions
None listed
Sponsors
Tampere University
Coxa, Hospital for Joint Replacement
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of osteoarthritis * Scheduled for primary hip or knee replacement
Exclusion criteria
* Arthritis other than osteoarthritis * Medication affecting glucose metabolism (excl. antidiabetic agents) * Not undergoing hip or knee replacement
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence (and severity) of hyperglycemia following primary hip or knee replacement | 3 days (average) | Follow-up covers postoperative hospital stay at the operating hospital, that lasts typically 2-5 days. |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of surgical-site infections | 1 year |
| Prevalence of glucose metabolism disorders and metabolic syndrome | Baseline |
Countries
Finland
Outcome results
None listed