Food Intake
Conditions
Keywords
Food Intake, Hunger, Lidocaine, Nose, smell
Brief summary
The purpose of this study is to determine whether the blood pressure medication, diltiazem, will temporarily decrease the sense of smell when given in a nasal spray which will then reduce food intake.
Detailed description
You will fast on your first visit. Complete questionnaire about taste and smell to insure you don't have a cold or anything that would interfere with sense of smell. Your nose will be checked. Blood pressure taken, and administer to you a spray with diltiazem 2, 4, 8 mg or a placebo. Your sense of smell will be tested at different time points.
Interventions
OTHERPlacebo spray
0, 30, 60, 90, 120, 180, and 240 minutes following the nasal spray yet no drug will be administered
DRUGDiltiazem
0, 30, 60, 90, 120, 180, and 240 minutes following the nasal spray Three Dilutions would be 5.5, 6.0 and 6.3 and the fourth at the filp of a coin randomly diluted.
Sponsors
Compellis Pharmaceuticals
Pennington Biomedical Research Center
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index (BMI) between 25 and 40 kg * Blood pressure in within normal range
Exclusion criteria
* Used tobacco products in the past month * Used a calcium channel blocker medication in the last month * used nasal sprays in the last month * have an abnormal sense of smell or abnormalities of the lining in your nose * female and have irregular menstrual periods * female and are nursing a baby or pregnant * female and have had a partial hysterectomy (still have ovaries)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evidence of blood pressure medication, diltiazem, will temporarily decrease the sense of smell when given in a nasal spray. | 3 weeks |
Countries
United States
Outcome results
None listed