Tuberculosis
Conditions
Keywords
tuberculosis, bone marrow transplant, diagnosis
Brief summary
The aim of this study is to estimate the usefulness of a T cell-based assay (i.e. Quantiferon-Gold In-Tube assay) for diagnosis of latent tuberculosis infection (LTBI) in bone marrow transplant recipients. For this purpose, the investigators enrolled bone marrow transplant recipients and observed the developement of tuberculosis after the transplantation.
Detailed description
All adult bone marrow transplant recipients admitted to Asan Medical Center will be enrolled. Quantiferon-Gold In-Tube assay will be performed. Isoniazid prophylaxis will be given only to patients with clinical risk factors (i.e. recent contact with active pulmonary TB patient or inadequate treatment history with abnormal CXR). However, isoniazid prophylaxis will be not given based on positive TST or positive Quantiferon-Gold In-Tube assay.
Interventions
None listed
Sponsors
Asan Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 16 or more * Bone marrow transplant recipients
Exclusion criteria
* Recent contact of patients with active pulmonary tuberculosis * Suspected active tuberculosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| development of tuberculosis | after transplantation |
Secondary
| Measure | Time frame |
|---|---|
| all cause mortality | after transplantation |
Countries
South Korea
Outcome results
None listed