Role of Indoor Pollutants on House Dust Mite Allergic Asthma

Aldehyde and Nitrogen Dioxide at Homes: Measurement of the Exposure and Their Role on Allergic Asthma

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01019291

Enrollment

Registered

2009-11-25

Start date

Unknown

Completion date

Unknown

Last updated

2015-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergic Asthma, Allergy to House Dust Mite

Keywords

Indoor pollutants

Brief summary

It seems that the aldehydes and NO2, at the levels found indoor, could be the aggravating factors for an allergic response. However this effect has not been demonstrated. The investigators plan to study the effect of exposure to standard doses of these pollutants on the bronchial reactivity as measured by bronchial challenge tests with dust mite extract in volunteers asthmatic, allergic to house dust mite.

Interventions

OTHERFormaldehyde and NO2 (Exposure to indoor pollutants)

Exposure to indoor pollutants (Formaldehyde and NO2) in a randomized way, followed by bronchial challenge test with house dust mite extract.

OTHERPlacebo (Exposure to indoor pollutants)

Exposure to indoor pollutants (placebo) in a randomized way, followed by bronchial challenge test with house dust mite extract.

Study design

Allocation

RANDOMIZED

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* M/F 18-50 years of age * History of intermittent HDM allergic asthma-FEV1 \> 80% * Non smokers or smokers with smoking \< 10 PY

Exclusion criteria

* Persistent asthma and FEV1\<80% * Allergic to pets and pets at home

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026