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Detecting Early Myocardial Infiltration w/Amyloid & Light Chain Deposition Disease in Multiple Myeloma Subjects

Role of Cardiac MR (CMR) In Detecting Features of Early Myocardial Infiltration With Amyloid and Light Chain Deposition Disease in Subjects With Multiple Myeloma

Status
Terminated
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT01018927
Enrollment
44
Registered
2009-11-25
Start date
2009-06-30
Completion date
2017-05-30
Last updated
2017-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Myeloma

Keywords

Cardiac MR (CMR), Early Myocardial Infiltration, Amyloid, Light Chain Deposition Disease, Multiple Myeloma

Brief summary

The purpose of this study is to see if MRI techniques can be used for early evaluation of cardiac amyloidosis which is sometimes seen in individuals with multiple myeloma. Cardiac amyloidosis is a medical disorder that decreases heart function.

Detailed description

The purpose is to investigate the use of multiple newer CMR techniques for early evaluation of cardiac amyloidosis in multiple myeloma.

Interventions

DEVICEAdministering three additional MRI images

Three additional MRI images to determine the role of cardiac MR (CMR) in detecting features of early myocardial infiltration

Sponsors

Siemens Molecular Imaging
CollaboratorINDUSTRY
University of Arkansas
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* All races and ethnic groups * Male and female ages 18-80 years of age * History of multiple myeloma * CMR study for evaluation for cardiac amyloidosis

Exclusion criteria

* Pregnant women * Subject with a metallic or electronic or other device that could be affected by the magnet

Design outcomes

Primary

MeasureTime frame
This study is to see if MRI techniques can be used for early evaluation of cardiac amyloidosis which is sometimes seen in individuals with multiple myeloma.The time frame is five additional minutes & three additional images during and MRI.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026