Soft Tissue Tumors
Conditions
Brief summary
To determine if MRI imaging can be used to accurately determine if a sarcoma is responding to the type of chemotherapy being used.
Detailed description
The purpose of this study is to determine if MRI imaging can be used to accurately determine if a sarcoma is responding to the type of chemotherapy being used or if it is ineffective early on in the treatment; instead of finding this out 2-3 months later. If it is determined that MRI can accurately diagnose tumor response, medications can be switched early on potentially improv8ing the patients'chances of recovery.
Interventions
PROCEDUREMRI Scan of soft tissue tumor
MRI scan will be completed at baseline (prior to start of subject's clinically ordered chemotherapy treatments.
Sponsors
National Institutes of Health (NIH)
University of Michigan
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Biopsy proven primary bone or soft tissue tumor 2. No previous treatment for this malignancy 3. Will be given chemotherapy before having surgery or radiation on the tumor. 4. Are able to undergo a MRI examination 5. If your tumor measures at least 1/2 inch in length.
Exclusion criteria
1. Younger than 3 yrs. of age or need general anesthesia(sedation that puts you to sleep) to have a MRI performed. 2. History of Renal Failure 3. Are not able to have a MRI performed for any reason such as you have a pacemaker or other implanted device that may malfunction or move because of the magnetic field inside the MRI room and scanner. 4. Have any history of an allergic reaction to gadolinium based contrast agents (a medication injected in a vein that helps create clearer MRI images. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To determine if MRI imaging can accurately determine if a sarcoma (tumor)is responding to the type of chemotherapy being used. | Baseline prior to chemo | To image and evaluate the size of the soft tissue tumor prior to chemotherapy treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MRI Scan | 3 weeks post start of chemo and end of chemo | To evaluate the size of the soft tissue tumor after start of chemotherapy to determine if the chemo is having any notable effect on tumor prior to surgery. |
Countries
United States
Outcome results
None listed